This clinical guide for nursing and other health care professionals, particularly advanced practice nurses, describes the extent of the problem of osteoporosis, the pathogenesis, clinical presentation, diagnostic testing, treatments, and current and emerging prevention strategies. The incorporation of clinical protocols and practice guidelines makes this an important reference for clinicians caring for patients of all ages as current research points to the need to help children and teenagers develop maximum bone density in the early years to prevent osteoporosis in later life.