Tuberculosis is a life-threatening lung infection that affects people of all ages. It is the second biggest cause of death from infectious diseases and is the most common cause of death amongst patients with HIV/AIDS. Education on the recognition of tuberculosis and the subsequent treatment of the disease is empirical to the prevention of wide-spread resistance. There is a lack of knowledge on how to treat coinfected and comorbid patients, this handbook offers the latest medical guidance and treatment options to equip physicians to manage such patients.