This volume contains papers related to the research conference, 'Symbolic Computation: Solving Equations in Algebra, Analysis, and Engineering', held at Mount Holyoke College (MA). It provides a broad range of active research areas in symbolic computation as it applies to the solution of polynomial systems. The conference brought together pure and applied mathematicians, computer scientists, and engineers, who use symbolic computation to solve systems of equations or who develop the theoretical background and tools needed for this purpose. Within this general framework, the conference focused on several themes: systems of polynomials, systems of differential equations, non commutative systems, and applications.