Widely spread all over Europe and the world, Content and Language Integrated Learning (CLIL) is the subject of great, interest as the ultimate frontier of linguistic and pedagogical research. It impinges on the general cognitive processes involved in learning, on language acquisition and on the development of digital competencies. This volume attests to the spreading of the new “CLIL literacy” in the frame of pluriliteracies, and derives theoretical reflections from case studies and experiential reports, thus addressing both academic and school instructors. It combines research from international CLIL experts with the critical perspectives of academics not directly involved in its instruction.