This book constitutes the refereed proceedings of the 15th International Conference on Artificial General Intelligence, AGI 2022, held as a hybrid event in Seattle, WA, USA, in August 2022.The 31 full papers presented in this book were carefully reviewed and selected from 61 submissions. The papers cover topics from foundations of AGI, to AGI approaches and AGI ethics, to the roles of systems biology, goal generation, and learning systems, and so much more. Additionally, this volume contains 13 posters.