This volume collects some of Giovanni Dosi's most important publications in the new millennium, following his earlier 2000 collection, Innovation, Organization and Economic Dynamics. It begins by offering quite a few advances in the analysis of individual learning in evolving environments, and of organizational structures and learning, thereby contributing to an emerging knowledge-centred theory of the firm and to a related theory of production. A second group of papers addresses the workings of markets, the importance of their institutional architectures, their diverse effectiveness as selection devices, and the evolutionary patterns of demand formation. A third set of chapters continues the exploration of the characteristics, drivers and performance outcomes of industrial evolution. The fourth part of the book is a reassessment of the role of history and path dependence in evolutionary processes. Finally, Part five addresses both the empirics and the modeling of the processes of growth and development nested into coupled evolution of technologies, corporate organizations and institutions.