This volume in the new American Heart Association Monograph Series presents a broad base of information at various levels for the application of exercise in cardiovascular health and patients with cardiovascular disease. With the growing interest in exercise and the designation by the American Heart Association of physical inactivity being the fourth major modifiable coronary risk factor, this publication should be of great interest to the clinician and/or the basic scientist. It brings together data from the level of the basic science researcher to the level of the clinician who has been involved in clinical trials and clinical evaluations