This outstanding issue of Medical Clinics of North America brings the reader up to date on important new approaches to coronary risk factors.  The most essential questions are answered, including the following.  Are new biomarkers needed?  How important is HDL?  LDL: The lower the better?  How much credit does triglyceride deserve?  Should family history scare you?  Is genomics ready for prime time? Some answers to these questions might surprise a practicing internist!  Other vital topics are discussed, including individualized statinization, pediatric statinization, use of polypill in different patient populations, coronary artery disease in women (menopause of EPCs?), and imaging for prevention.