Child and Adolescent psychiatrists frequently see patients with medical disorders that impact their psychiatric care in various ways. This issue covers oncology, inflammatory bowel disease, siblings with chronic illnesses, obesity, genetic abnormalities, transplants, very premature infants through the lifespan, asthma, diabetes mellitus, HIV, palliative care, cystic fibrosis, sickle cell disease, headaches, unexplained physical complaints, and epilepsy. Each article provides an overview of the medical disorder itself, as well as the special considerations required for the psychiatric care of that patient.