This book offers a dynamic perspective on regional entrepreneurship, knowledge, innovation and economic growth, with a particular focus on the role that history and culture play. The authors provide comprehensive empirical analyses offering unique insights into the spatial patterns of long-term differences of regional self-employment, new business formation, cultures of entrepreneurship, innovation activities, and development. Policy implications from the analyses and a discussion of important avenues for future research complete this unique book combining history, culture, and entrepreneurship.