This report marks the first of what is expected to be a series of assessments of various global health problems, and this first effort begins with the conceptualization of health as a global issue. It explores the relationship between health and economic growth, trade, innovation, global security and global governance. It focuses in particular on infectious diseases as a significant global health challenge, and looks to the origin, causes, and effectiveness of various interventions employed for different epidemics. In evaluating the global response to pandemics, it looks at each in terms of the viability and effectiveness of regional and cross-border collaboration to deploy health care systems, surveillance, lab testing, communication, and human resources and equipment.