In this second volume, the authors examine the role that Einstein's mass–energy equation played in the development of two important theories in early twentieth century physics: de Broglie's "matter waves" and general relativity as a theory of gravitation.

They also discuss the first empirical confirmation of E = mc2 by Cockcroft and Walton, and investigate the somewhat surprising fact that Cockcroft and Walton's paper reporting their result makes no mention of either Einstein or his famous equation.

Finally, they examine some of the contemporary debates concerning how the mass–energy relation should be taught and understood philosophically, and they close with some suggestions for future research.