This book constitutes the refereed proceedings of the 34th International Conference on Advanced Information Systems Engineering, CAiSE 2022, which was held in Leuven, Belgium, during June 6-10, 2022.The 31 full papers included in these proceedings were selected from 203 submissions. They were organized in topical sections as follows: Process mining; sustainable and explainable applications; tools and methods to support research and design; process modeling; natural language processing techniques in IS engineering; process monitoring and simulation; graph and network models; model analysis and comprehension; recommender systems; conceptual models, metamodels and taxonomies; and services engineering and digitalization.