Volume Five in the Handbook of Stress series offers comprehensive cover of the interactions between stress, the immune system, immune responses, and Inflammation. The volume provides easy and in-depth access to these themes, both for research and clinical practice. There have been significant advances in our understanding of the interaction of stress, inflammation and the immune response to viral, bacterial and other challenges. Integrated closely with new behavioral findings and relevant to human conditions, this volume offers readers cutting-edge information of prime interest for neuroscientists, psychiatrists, neurologists, neuroendocrinologists, endocrinologists immunologists and general physicians, and researchers, and students, in similar and related themes. The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier’s Encyclopedia of Stress (2000 and 2007). Volume 5 is ideal for graduate students, post-doctoral fellows, faculty, and clinicians interested in the interactions between stress, the immune system and inflammation.