Based on actual historical events, "One Thousand White Women" is the poignant story of May Dodd's journey west. Committed to an insane asylum by her blueblood family for an affair with a man beneath her station, May finds that her only hope of freedom is to participate in a secret government program whereby women from the "civilized" world become the brides of Cheyenne warriors. She soon falls in love with John Bourke, a gallant young army captain, even though she is married to the great chief Little Wolf. Caught between two worlds and two men, Dodd is forced to make tough decisions that will change her life forever.