In this issue of Emergency Medicine Clinics, guest editors Drs. Michael Gottlieb and Alexis Salerno bring their considerable expertise to the topic of Clinical Ultrasound in the Emergency Department. Top experts explore various aspects of ultrasound in the ED, including physics/knobology/artifacts; airway/thoracic; cardiac (LV + RV); aorta; GI (biliary and bowel); GU (renal, bladder testicular) OB/GYN; and more.