This issue of Anesthesiology Clinics, edited by Dr. Nabil Elkassabany and Dr. Edward Mariano, focuses on Regional Anesthesia, with topics including: Current evidence related to regional analgesia and hip surgery; Updates on billing and coding and establishing an acute pain service in private practice; Establishing a home catheter program for orthopedic surgery in pediatric patients or more broadly: updates on regional anesthesia for pediatric orthopedic surgery; Enhanced recovery after shoulder arthroplasty; Perioperative management of patient on opioid agonist antagonist therapy; Outcome metrics to be considered for regional anesthesia and acute pain medicine; Updates on multimodal analgesia (intransal ketorolac, IV acetmenophen, newer NSAIDS) for orthopedic surgery; Updates in enhanced recovery pathway for knee replacement versus updates outpatient knee replacement; Updates on new technology for regional anesthesia (peripheral nerve stimulators and cryotherapy); and Regional anesthesia and analgesia for the poly trauma patients.