Innovative Entrepreneurship as a Collaborative Effort: An Institutional Framework synthesizes the authors previous work to draw conclusions and identify new directions. It puts the spotlight on collaborative innovation blocs (CIB) and improves our understanding of how and why entrepreneurial plans are formulated and revised over time. The authors envision an institutional framework that improves the “antifragility” of CIBs and the economic system as a whole, thus enabling individual CIBs and the broader economic system to thrive when faced with adversity. Section 2 discusses how and when collaborations occur in the market order and identify entrepreneurship as an inherently collaborative function. Section 3 describes the collaborative innovation bloc and each of its skill components: entrepreneurs, inventors, early- and later-stage-financiers, key personnel, and customers. Section 4 identifies the most important critical areas affecting CIBs, thus demonstrating the usefulness of this perspective for understanding when innovation comes (and does not come) about. The last section discusses the key takeaways and limitations of the perspective before highlighting fruitful avenues for future research.