John Seraph's life is jeopardized when he begins looking for a missing woman and learns she was involved with one of his brothers and a New York State Senator. Family Ties recounts how John Seraph is asked by a former classmate to help find his missing sister, because John's father is Stefano Angelo, head of the local organized crime family. John has not seen or dealt with his family in over three years since he walked away from them over moral differences about the criminal organization. John agrees to help and in the course of his investigation he learns a disturbing secret about the missing girl which leads him to her workplace and confronting New York State Senator Kingsley Addar and then his own brother Michael. As John digs deeper his life becomes endangered, but he is determined to learn the truth and see justice served.