Untying the Gordian Knot proposes a new creative synthesis, the Logoi framework, which is radically inclusive and incorporates both actuality and potentiality, to show how the fundamental notions of process, logic and relations, woven with triads of input-output-context and quantum logical distinctions, can resolve a baker’s dozen of age-old philosophic problems. Further, it leverages a century of advances in quantum physics and the Relational Reality interpretation pioneered by Michael Epperson and Elias Zafiris (2013), augmented by the independent research of Ruth Kastner (2013) and Hans Primas (2017), to resolve long-standing issues in understanding quantum physics. Adding to this, advances in information and complex systems, semiotics and process philosophy are utilized to show how multiple levels of context, combined with relations, including potential relations, that are both local and local-global, can provide a grounding for causation, emergence and physical law. Finally, the Logoi framework goes beyond standard ways of knowing, that of context independence (science) and context focus (arts, humanities), to demonstrate the inevitable role of ultimate context (meaning, spiritual dimension) as part of a transformative ecological vision, which is urgently needed in these times of human and environmental crises.