A number of interpolation problems are considered in the Schur class of $ptimes q$ matrix valued functions $S$ that are analytic and contractive in the open unit disk. The interpolation constraints are specified in terms of nontangential limits and angular derivatives at one or more (of a finite number of) boundary points. Necessary and sufficient conditions for existence of solutions to these problems and a description of all the solutions when these conditions are met is given. The analysis makes extensive use of a class of reproducing kernel Hilbert spaces ${mathcal{H}}(S)$ that was introduced by de Branges and Rovnyak. The Stein equation that is associated with the interpolation problems under consideration is analyzed in detail. A lossless inverse scattering problem is also considered.