The last! This volume closes the Séminaire de Probabilités, a long and rich series that started in 1966 under the name Séminaire de Probabilités de Strasbourg. In addition to a tribute to our colleague Dominique Lépingle, who passed away in December 2021, it presents a selection of texts that reflect recent research streams in probability, including material on random matrices, rough analysis, Markov processes, and subordinators. The featured contributors are J. Bacckhoff, Q. Berger, L. Betencourt, E. Bodiot, A. Bonami, A. Cox, S. Dallaporta, M. Defosseux, F. Delarue, N. Demni, M. Février, A. Grass, B. Hass, M. Huesmann, L. I. Hernandez Ruíz, E. Kahn, L. Miclo, W. Salkeld, and M. Zani.