The two-volume set LNCS 6640 and 6641 constitutes the refereed proceedings of the 10th International IFIP TC 6 Networking Conference held in Valencia, Spain, in May 2011. The 64 revised full papers presented were carefully reviewed and selected from a total of 294 submissions. The papers feature innovative research in the areas of applications and services, next generation Internet, wireless and sensor networks, and network science. The first volume includes 36 papers and is organized in topical sections on anomaly detection, content management, DTN and sensor networks, energy efficiency, mobility modeling, network science, network topology configuration, next generation Internet, and path diversity.