The syringe driver is a portable battery-operated device that delivers a continuous subcutaneous infusion, often the most useful method of drug administration when other routes are inappropriate. Palliative care patients frequently have multiple symptoms that require the use of numerous drugs; as the patient's condition deteriorates, the oral route is often no longer suitable and the syringe driver ensures continued symptom control. This route increases patient comfort as it avoids the need for repeated injections, plasma concentration levels of drugs remain constant, and it maintains the patient's sense of independence. The syringe driver can be essential in the last 48 hours.