This volume provides
a sound basis for the molecular investigation of NLR function in health and
disease. Chapters focus on of innate immune receptors, “atypical”
inflammasomes, biochemical and novel bioluminescence
techniques for the measurement of IL-1b,
bioluminescent probe, biochemical and microscopy
techniques, techniques to measure caspase-1 activation, cell
free systems for the study of inflammasome function, and inflammasome
activation. Written in the highly successful Methods
in Molecular Biology series format, chapters include introductions to their
respective topics, lists of the necessary materials and reagents, step-by-step,
readily reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls.

Authoritative
and cutting-edge, NLR Proteins: Methods
and Protocols aims to ensure successful results in the further study of
this vital field.