This book addresses the most innovative topics on silicon to ensure sustainability in agriculture, including advances in nanotechnology and the impact on human health. It provides innovative information on the mineral nutrition of plants with a focus on the beneficial element silicon that has attracted the attention and interest of researchers. This is happening because silicon is the only element in plant nutrition that is capable of mitigating the greatest number of stressful events during plant cultivation. Faced with climate change associated with disease pressure due to the use of transgenic cultivars that decreases genetic variability and increases the occurrence of stress in crops. Associated with this, there is a need to reduce the use of chemical pesticides in crops to favor agro-environmental sustainability and thus increases the need for the use of silicon in agriculture. This is important because the main goal of plant mineral nutrition is to meet the demand of the plant and consequently of man and his nutritional requirements, but there is a lack of work to integrate the benefits of Si in plants and consequently its reflections on human health. The information in this work will drive further research to expand knowledge and the benefits of Si in sustainable agriculture and human health, and therefore, the target audience would be researchers, professors, students from universities and research institutes, as well as company technicians.