This book includes selected peer-reviewed papers presented at the International Conference on Modeling, Simulation and Optimization (CoMSO 2022), organized by National Institute of Technology, Silchar, Assam, India, during December 21–23, 2022. The book covers topics of modeling, simulation, and optimization, including computational modeling and simulation, system modeling and simulation, device/VLSI modeling and simulation, control theory and applications, and modeling and simulation of energy systems and optimization. The book disseminates various models of diverse systems and includes solutions of emerging challenges of diverse scientific fields.