This book gathers the proceedings of the 11th International Conference on E-Health and Bioengineering, EHB 2023, held in hybrid form on November 9–10, 2023, in/from Bucharest, Romania. This first volume of a three-volume set reports on advances in medical devices and instrumentation, for a wide range of applications including medical diagnosis and therapy, rehabilitation, and medical data management. It also describes the use of artificial intelligence in medicine for detecting and modeling diseases, health monitoring, medical decision making, and related applications. All in all, this book offers extensive and timely information to researchers and professionals in bioengineering, health informatics and related interdisciplinary fields.