The fourth edition of The Cell has been thoroughly updated to reflect major advances in the field including the role of microRNAs in the regulation of gene expression, advances in stem cell biology as well as oncogenes and the rational design of new anticancer drugs. While retaining the overall structure and pedagogy that made previous editions so successful, the fourth edition now includes additional chapters on Programmed Cell Death and the Maintenance of Adult Tissues. There is also significant new material on topics like Signaling Networks, Cell-Matrix Interactions and Bioinformations to keep The Cell fresh, vibrant and perpetually appealing to students.