Major excavations on the site of the Augustinian priory and hospital of St Mary Spital uncovered the remains of over 10,500 human skeletons. Unprecedented accuracy of dating and phasing of the cemetery was achieved using a targeted programme of stratigraphic and radiocarbon dating techniques, resulting in four chronological periods of burials. Osteological analysis of a sample of 5387 skeletons has provided a unique insight into the lives of medieval Londoners from the 12th to the early 16th centuries. Many of the skeletons showed evidence of disease and injury and the results of this major project are integrated into a biocultural framework, which includes the recurrent famines and epidemics of the time.