In this issue of Otolaryngologic Clinics, guest editors Drs. Joni K. Doherty and Michael Setzen bring their considerable expertise to the topic of Comprehensive Management of Headache for the Otolaryngologist. As many types of headache tend to masquerade as sinus headache, an understanding of the peripheral mechanisms of specific headache types is essential for otolaryngologists to effectively diagnose and treat patients, according to a study published in the American Journal of Otolaryngology. In this issue, top experts in the field address key issues such as novel devices for sinus headache, headache diagnosis in children and adolescents, headache and pregnancy, side-locked and nummular headaches, and much more.