Focusing on e-health and adolescents, this second issue of Adolescent Medicine: State of the Art Reviews is a stand-alone reference and practice tool with evidence-based reviews that detail advances in the diagnosis and management of a wide range of health problems affecting adolescents. For more than 10 years, Adolescent Medicine: State of the Art Reviews (formerly published by Elsevier and previously titled Adolescent Medicine Clinics) has been the official publication of the AAP Section on Adolescent Medicine. The second issue is Volume 18, Number 2.