This book explores how the writers, poets, thinkers, historians, scientists, dilettantes and frauds of the long-nineteenth century addressed the “limit cases” regarding human existence that medicine continuously uncovered as it stretched the boundaries of knowledge. These cases cast troubling and distorted shadows on the culture, throwing into relief the values, vested interests, and power relations regarding the construction of embodied life and consciousness that underpinned the understanding of what it was to be alive in the long nineteenth century. Ranging over a period from the mid-eighteenth century through to the first decade of the twentieth century—an era that has been called the ‘Age of Science’—the essays collected here consider the cultural ripple effects of those previously unimaginable revolutions in science and medicine on humanity’s understanding of being.