This book constitutes the refereed proceedings of the Second International Workshop on Human-Computer Interaction, Tourism and Cultural Heritage, HCITOCH 2011, held in Córdoba, Argentina, in September 2011. The 14 revised full papers presented were carefully reviewed and selected from various submissions. The volume is intended to be a meeting point of all those who freely wish to boost and perfect the set of strategies and techniques to improve the human-computer interaction, tourism, and cultural heritage.