This book reviews the horizons and frontiers of humanism as they interact with the science of life in the universe, now generally known as "astrobiology". As one of the most important conversations of our time, the existence of life itself raises deep questions that are meaningful to both astrobiology and humanism. The text discusses current disagreements in this intercultural dialogue, which are shown to be solely due to the widespread delusion that the horizons and frontiers of science can be ignored.