This book constitutes the proceedings of the 13th International Conference on Design Science Research in Information Systems and Technology, DESRIST 2018, held in June 2018 in Chennai, India.  The 24 full papers presented in this volume were carefully reviewed and selected from 96 papers. The contributions are organized in topical sections named: HCI and Design, Design Foundations, Design Foundations, Design in Healthcare, Advances in Data Science and Analytics, ICT for Development, Designing Cybersecurity, and Design Applications.