This book gives an overview of Cloud Computing (CC) and presents a literature review explaining the development of CC. Selected frameworks are discussed, including those suitable for this research. Technical and organisational challenges for CC are also identified. This book focuses on organisational challenges and recommendations to address organisational challenges. To help organisations achieve good Cloud design, deployment and services, there is a need for the proposal and development of a framework, the Cloud Computing Business Framework (CCBF), which explains how three research questions are connected together. The CCBF is a conceptual and an architectural framework to be validated through modelling, simulation, experiments and hybrid case studies. The architecture of the CCBF is presented to explain how different key areas can relate to each other and fit into the framework. Results of case studies, simulations, modelling and experiments are used to validate CCBF and are discussed in details which collaborators find results of CCBF useful for their Cloud adoption. Selected results have been published including four journals and one book chapter. Finally, future work plans are proposed and followed-up steps are explained.