Following a long-term international collaboration between leaders in cosmology and the philosophy of science, this volume addresses foundational questions at the limit of science across these disciplines, questions raised by observational and theoretical progress in modern cosmology. Space missions have mapped the Universe up to its early instants, opening up questions on what came before the Big Bang, the nature of space and time, and the quantum origin of the Universe. As the foundational volume of an emerging academic discipline, experts from relevant fields lay out the fundamental problems of contemporary cosmology and explore the routes toward finding possible solutions. Written for graduates and researchers in physics and philosophy, particular efforts are made to inform academics from other fields, as well as the educated public, who wish to understand our modern vision of the Universe, related philosophical questions, and the significant impacts on scientific methodology.