This book presents an overview of membrane organisation and lipid rafts in the cell and artificial membranes. The topics analysed in this book cover a broad spectrum of functions played by lipid rafts in membrane organisation within the cell and artificial membranes, and presents new information in this area of research. The topics analysed include: fluid-mosaic cell membrane structure from cellular control and domains to extracellular vesicles; lipid rafts in binary lipid/cholesterol membranes; membrane assembly and lipid rafts in the cell and artificial membranes; the effect of lipid peroxidation; drugs, delivery systems and membrane organisation in model and cell membranes; role of sphingomyelin on membrane domain formation and its influence in protein interaction focusing on the nanometer scale; lipid rafts and cell adhesion; mutual modulators of cell signaling; and finally, roles of glycosphingolipids in the regulation of the membrane organisation and cell signaling in lipid rafts.