This two volume set LNCS 10177 and 10178 constitutes the refereed proceedings of the 22nd International Conference on Database Systems for Advanced Applications, DASFAA 2017, held in Suzhou, China, in March 2017.  The 73 full papers, 9 industry papers, 4 demo papers and 3 tutorials were carefully selected from a total of 300 submissions. The papers are organized around the following topics: semantic web and knowledge management; indexing and distributed systems; network embedding; trajectory and time series data processing; data mining; query processing and optimization; text mining; recommendation; security, privacy, senor and cloud; social network analytics; map matching and spatial keywords; query processing and optimization; search and information retrieval; string and sequence processing; stream date processing; graph and network data processing; spatial databases; real time data processing; big data; social networks and graphs.