This book gathers the proceedings of The Hadron Collider Physics Symposia (HCP) 2005, and reviews the state-of-the-art in the key physics directions of experimental hadron collider research. Topics include QCD physics, precision electroweak physics, c-, b-, and t-quark physics, physics beyond the Standard Model, and heavy ion physics. The present volume serves as a reference for everyone working in the field of accelerator-based high-energy physics.