There are two new themes to medical education today: the integration of the basic and clinical sciences and the use of case histories and problem solving to encourage active learning. This is the first genetics text for medical students to incorporate these major changes. Based on the Harvard New Pathways model, this book integrates molecular and clinical genetics, organized around case histories and didactic text, which covers the basic principles of today's genetics. Each case history is explored from three points of view: classical genetic, molecular genetic, and clinical. Each chapter ends with a clinical problem which will illustrate and emphasize the points already learnt. The book progresses from simple to more complex concepts emphasizing important principles and setting groundwork for application of molecular and clinical genetics to the everyday practice of medicine.