Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine presents thinking and front-line research addressing calcium and phosphate homeostasis and related clinical problems. Major topics include calcium and phosphate transport in the mammalian body and some of its defects; several aspects of hormonal control of calcium and phosphorus metabolism, including PTH-related peptide; and basic and clinical aspects of bone and bone diseases. Other topics include calcium entry and extrusion mechanisms, secondary osteoporosis, how bone cells translocate phosphate needed to bone mineral, and the culture of renal and intestinal cells capable of transporting calcium in vitro. The book also features two prize-winning contributions; one deals with the characterization of a major calcium transport protein, calbindin D-9K, while the other discusses how the osteoclast, the bone-resorbing cell, is feedback-regulated.

Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine provides plenty of useful information for basic and clinical scientists alike, including biochemists, physiologists, cell biologists, pharmacologists, internists, orthopedic surgeons, dentists, and pathologists.

Contributions by: Ernesto Carafoli, Lawrence G. Raisz, Robert H. Wasserman, Jean-Philippe Bonjour, David V. Cohn, T. John Martin, Alberta Zamboni Zallone, Anna Teti