The electoral success of secessionist parties in Catalonia and Scotland over the last decade, together with Brexit and the support for Eurosceptic parties in many EU member states, have prompted a rethink of many taken-for-granted notions about politics in Spain, the UK and the EU. Secessionist parties in Catalonia and Scotland often combine calls for independence with support for the EU, but independence for Catalonia might entail the loss of EU membership. In the UK, Scotland voted for the UK to remain in the EU, yet it was forced to leave the Union along with the rest of the country: what effect has Brexit had on Scottish independence claims? Through comparing Catalonia and Scotland, this short volume aims to contribute to debates on, and advance knowledge of, visions of independence and integration, how they interrelate in Europe’s emergent political order, and what they entail for European integration and democracy in the EU.