The reemergence of tuberculosis is now a major health problem around the world. This often fatal disease persists as the largest cause of death from a single infectious agent. The editor, a leading figure in tuberculosis research, has gathered a team of acknowledged scientific and clinical experts from around the world to bring together the most current body of information on all aspects of tuberculosis its global importance, epidemiology, molecular biology, and immunology. The authors discuss fundamental questions about the biology, genetics, mechanisms of pathogenicity, mechanisms of resistance, and drug development strategies that are likely to provide important new knowledge about TB and new interventions to prevent and treat this disease. Tuberculosis is necessary reading for all microbiologists, clinicians, and public health officials concerned with the resurgence and spread of tuberculosis.