The Pygmalion Effect takes place in the year 2104 CE when genetically-enhanced intelligence has split the world into two classes, the rich and the poor. The young protagonist, Corbin, lives on the burned out streets of Boston, barely scraping by for food and shelter. Through manipulation, infiltration, and pure genius, he must fight back against the system and try to dismantle a massive plot aimed at killing his people in an attempt to cleanse the world of all non-enhanced beings.