This is the first volume of original commissioned papers on the subject of Newton and empiricism. The chapters, contributed by a leading team of both established and younger international scholars, explore the nature and extent of Newton's relationship to a variety of empiricisms and empiricists. Among the many significant contributions of the volume are a detailed engagement with Newton's optical writings, a careful contextualization of Newton's methods in seventeenth century context, a critical analysis of the ways in which Locke and Hume responded to Newton, and a history of the reception of Newton's methods in astronomy.