GeoComputation and Public Health is fundamentally a multi-disciplinary book, which presents an overview and case studies to exemplify numerous methods and solicitations in addressing vectors borne diseases (e.g, Visceral leishmaniasis, Malaria, Filaria). This book includes a practical coverage of the use of spatial analysis techniques in vector-borne disease using open source software solutions. Environmental factors (relief characters, climatology, ecology, vegetation, water bodies etc.) and socio-economic issues (housing type & pattern, education level, economic status, income level, domestics’ animals, census data, etc) are investigated at micro -level and large scale in addressing the various vector-borne disease. This book will also generate a framework for interdisciplinary discussion, latest innovations, and discoveries on public health. The first section of the book highlights the basic and principal aspects of advanced computational practices. Other sections of the book contain geo-simulation, agent-based modeling, spatio-temporal analysis, geospatial data mining, various geocomputational applications, accuracy and uncertainty of geospatial models, applications in environmental, ecological, and biological modeling and analysis in public health research. This book will be useful to the postgraduate students of geography, remote sensing, ecology, environmental sciences and research scholars, along with health professionals looking to solve grand challenges and management on public health.