These eleven essays originally delivered as the annual Louis J. Luzbetak Lectures at the Catholic Theological Union in Chicago focus on the relationship between mission and culture. The authors include missiologists Jos M. de Mesa, Darrell L. Whiteman, Aylward Shorter, John Kirby, and Angelyn Dries, and anthropolgists Linda E. Thomas, Anthony J. Gittens, and Philip Gibbs, and theologians Gemma T. Cruz and Robert J. Schreiter. Moving from Asia to Africa to North America, the essays probe the dynamics of the intersection of mission work and indigenous culture and demonstrate how essential it is for a missioner to have an in-depth understanding of the importance of culture.