This book provides an accessible and up to date overview of the foundational issues about both emerging constructive understandings of the digital era and still hidden and ignored aspects that could instead be dramatically relevant in the future, in the process of a technological humanism. The book offers relevant scientific and ethical questions bringing together professionals and researchers, from different professional and disciplinary fields, who have a shared interest in investigating operative aspects of technological, digital and cultural transitions of humans and their capacity of building human societies. The challenges are clear but there is a lack of an epistemological, anthropological, economic and social agenda that would enable a drive to such transitions towards a technological humanism.